BLUP Genotype Imputation for Case-Control Association Testing with Related Individuals and Missing Data
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چکیده
منابع مشابه
BLUP Genotype Imputation for Case-Control Association Testing with Related Individuals and Missing Data
We consider the problem of case-control association testing in samples that contain related individuals, where we assume the pedigree structure is known. Typically, for each marker tested, some individuals will have missing genotype data. The MQLS method has been proposed for association testing in this situation. We show that the MQLS method is equivalent to an approach in which missing genoty...
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ژورنال
عنوان ژورنال: Journal of Computational Biology
سال: 2012
ISSN: 1066-5277,1557-8666
DOI: 10.1089/cmb.2012.0024